Main Menu Navigation

Xhance (fluticasone propionate) nasal spray logo

For chronic rhinosinusitis (CRS)

TIME TO EXHALE

with XHANCE

Experience what relief could feel like with a different kind of treatment

Exhaling helps deliver the medicine to where it is needed

Designed to drive the medicine deep into the nasal cavity, the site of inflammation in chronic rhinosinusitis
Closes a structure in the back of the mouth called the soft palate, which helps prevent drainage of the medicine into the throat

Press the bottle to activate the spray
Soft palate is sealed closed when you exhale
Medicine is released into your airflow
Flexible mouthpiece

Designed to drive the medicine deep into the nasal cavity, the site of inflammation in chronic rhinosinusitis
Closes a structure in the back of the mouth called the soft palate, which helps prevent drainage of the medicine into the throat

Press the bottle to activate the spray
Soft palate is sealed closed when you exhale
Medicine is released into your airflow
Flexible mouthpiece

XHANCE helped improve the primary symptoms of chronic rhinosinusitis

Nasal
congestion

Facial pain
or pressure

Runny nose and
postnasal drip

Reduced or loss
of sense of smell

In recent studies, some people using XHANCE experienced a reduction in symptom flare-ups* through 24 weeks.

*Flare-ups are a worsening of symptoms requiring antibiotics or an acute care visit.

Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE.

How to take XHANCE: Seal, Aim, Blow, Press

Prime XHANCE before first use. Remove the cap and shake away from your face and eyes. With the cap removed, keep the bottle away from your face and pump 7 times, or until you see a fine mist. If you have not used XHANCE for 7 or more days, re-prime by spraying 2 times before use.

Diagram of
sealing XHANCE between the nosepiece and nostril

STEP 1: SEAL

First, shake. Then, place your fingers on the indented grip BELOW the mouthpiece.

Do not place your fingers above or over the flexible mouthpiece.

Gently insert the nosepiece into your nose and the flexible mouthpiece into your mouth.

Keep a tight seal between the nosepiece and your nostril.

STEP 2: AIM

Aim the device upward between your eyes.

Diagram of
blowing into the XHANCE mouthpiece

STEP 3: BLOW

Take a deep breath and blow hard into the mouthpiece.

Imagine you are blowing up a balloon.

Blow, don’t sniff, and don’t block your other nostril.

Diagram
of blowing XHANCE into the nasal passage

STEP 4: PRESS

Keep blowing hard as you press the bottle with your thumb, releasing the medicine deep into your nasal passages.

Repeat these steps for your other nostril.

DID I DO IT RIGHT?

Shake before each use
Keep a snug fit in nose and mouth
Continue blowing hard while pressing the bottle
Do not sniff, inhale, or block second nostril
Administer only the prescribed number of sprays in each nostril

FOR BEST RESULTS

Use XHANCE regularly, twice daily. Follow your doctor’s instructions, with either one or two sprays per nostril
Do not take more than your prescribed dose of XHANCE each day
Remember to refill your prescription
monthly or as prescribed by your doctor

If you have questions about how to use XHANCE, refer to the Instructions for Use.

If your commercial health insurance covers XHANCE, your out-of-pocket cost could
be as little as $0 using the XHANCE copay card

Eligible, commercially insured patients can pay as little as $0 for their prescription of XHANCE.^†

Download copay card >

Be sure to download or print your XHANCE
Copay Card to receive available savings.

^†Terms and conditions apply. Patients must be commercially insured. May not be used if the patient is enrolled in a government-funded prescription insurance program.

IMPORTANT SAFETY INFORMATION

APPROVED USES

XHANCE is a prescription medicine used to treat:

chronic rhinosinusitis with nasal polyps in adults.
chronic rhinosinusitis without nasal polyps in adults.

It is not known if XHANCE is safe and effective in children.

Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE.

Do not use XHANCE more often than prescribed.

Do not take more than your prescribed dose of XHANCE each day.

Before using XHANCE, tell your healthcare provider about all of your medical conditions, including if you:

have an immune system problem
have any type of viral, bacterial, or fungal infection
are exposed to chickenpox or measles
have liver problems
are pregnant or plan to become pregnant. It is not known if XHANCE may harm your unborn baby
are breastfeeding or plan to breastfeed. It is not known if XHANCE passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take. Especially tell your healthcare provider if you take antifungal or anti-HIV medicines as they may interact with XHANCE. This may cause serious side effects.

XHANCE may cause serious side effects, including:

Nasal problems. Symptoms of nasal problems may include nose bleeds, crusting in the nose, sores (ulcers) in the nose, or a whistling sound when you breathe.
Fungal infections (thrush) in your nose and throat. Tell your healthcare provider if you have any redness or white colored patches in your nose or mouth.
Slow wound healing. You should not use XHANCE until your nose has healed if you have a sore in your nose, have had surgery on your nose, or if your nose has been injured.
Eye problems including glaucoma and cataracts. You should have regular eye exams while you use XHANCE. Call your healthcare provider if you have vision changes while using XHANCE.
Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, or low blood pressure.
Weakened immune system and increased chance of getting infections. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE. If you come in contact with someone who has chickenpox or measles, call your healthcare provider right away. Tell your healthcare provider about any signs or symptoms of infection such as: fever, pain, aches, chills, feeling tired, nausea, or vomiting.
Reduced adrenal function. This potentially life-threatening condition can happen when you stop taking oral corticosteroids (such as prednisone) and start taking inhaled corticosteroids. Reduced adrenal function can also happen when nasal corticosteroids, such as XHANCE, are used at a dose higher than the usual dose or in people who are susceptible at the usual dose. This may be more likely to happen after surgery or during periods of stress. Tell your healthcare provider right away about any signs and symptoms of reduced adrenal function, such as tiredness, weakness, nausea and vomiting, or low blood pressure.
Weak bones (osteoporosis). Tell your healthcare provider if you have weak bones before using XHANCE.
Slowed growth in children. A child’s growth should be checked often.

The most common side effects of XHANCE in adults with chronic rhinosinusitis with nasal polyps include: nose bleeds, sores (ulcers) in your nose, pain or swelling of your nose or throat, redness in your nose, nasal congestion, sinus infection, and headache.

The most common side effects of XHANCE in adults with chronic rhinosinusitis without nasal polyps include: nose bleeds, headache, and pain or swelling of your nose or throat (nasopharyngitis).

These are not all the side effects of XHANCE. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information and Instructions for Use.